Fabian Ackle

About me

I am a PhD candidate in the Seeger Lab at the University of Zurich. My research focuses on protein trafficking in the early secretory pathway. I am developing and applying methods based on mass spectrometry, long-read sequencing, and peptide barcoding to study cargo receptors through high-throughput mutational scanning. Additionally, my research interests include single-domain antibodies (nanobodies) and their application in structural biology.

Google Scholar orcid.org/0000-0002-7199-5004 GitHub

Contact

Follow me on Twitter @f_ackle, Bluesky @fabianackle.ch or write me an email fackle@imm.uzh.ch.

Publications

Rapid detection and capture of clinical Escherichia coli strains mediated by OmpA-targeting nanobodies

M Sorgenfrei, LM Hürlimann, A Printz, F Wegner, D Morger, F Ackle, MM Remy, G Montowski, H Keserue, A Cuénod, F Imkamp, A Egli, PM Keller, MA Seeger - Communications Biology, 2025
DOI: 10.1038/s42003-025-08345-9

Rigid enlargement of sybodies with antibody fragments for cryo-EM analyses of small membrane proteins

F Ackle, S Thavarasah, JC Earp, MA Seeger - Scientific Reports, 2025
DOI: 10.1038/s41598-025-92950-5

Flycodes enable simultaneous preclinical analysis for dozens of antibodies in single cassette-dosed mice

JD Walter, M Beffinger, P Egloff, I Zimmermann, LM Hürlimann, F Ackle, M Seifert, S Kobold, JV Berg, MA Seeger - PNAS, 2025
DOI: 10.1073/pnas.2426481122

Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation

L Loeff, A Kroupova, I Asanovic, FM Boneberg, MM Pfleiderer, L Riermeier, A Leitner, A Ferdigg, F Ackle, J Martinez, M Jinek - NSMB, 2025
DOI: 10.1038/s41594-025-01516-6

Molecular architecture of the human tRNA ligase complex

A Kroupova, F Ackle, I Asanović, S Weitzer, FM Boneberg, M Faini, A Leitner, A Chui, R Aebersold, J Martinez, M Jinek - Elife, 2021
DOI: 10.7554/eLife.71656